© ACEIs decrease the production of Angiotensin II through the inhibition of Angiotensin Converting Enzyme. Decreased production of Angiotensin II, results in to vasodilation causing reduction of blood pressure. The function of a failing heart could be improved by lowered blood pressure making it easier for the heart to pump blood.
© ACEIs can interact significantly with many drugs including Aliskiren, Potassium sparing diuretics, Potassium supplements, Cyclosporine, Trimethoprim, Angiotensin Receptor Blockers (ARBs), mTOR Inhibitors, Alteplase, Lithium, Azathioprine, Antidiabetics and NSAIDs.
© It is contraindicated to use ACEIs along with Aliskiren concomitantly, due to increased risk of Hyperkalemia, Renal impairment and Hypotension.
© Severe arrhythmias may occur in patients taking ACEIs and Potassium Sparing Diuretics (Spiranolactone, Amiloride, Triamterene, etc.), Potassium Suplements, Cyclosporine or Trimethoprim, due to increased risk of Hyperkalemia.
© Coadministration of ACEIs and Angiotensin receptor blockers (ARBs) (Losartan, Valsartan, Candesartan, etc.) results in increased risk of adverse events (Hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure).
© The risk of Angioedema might be elevated by concomitant use of ACEIs and Mammalian Target of Rapamycin (mTOR) inhibitors (Sirolimus, Everolimus, Deforolimus, etc.).
© Administration of Alteplase in patients taking ACEIs increases the bradykinin levels and elevates the risk of Orolingual angioedema.
© Concomitant use of ACEIs and Lithium may result in to Lithium toxicity (weakness, tremor, excessive thirst, confusion).
© Anemia or Leukopenia may occur in patients taking ACEIs and Azathioprine due to myelosuppression.
© Increased risk of Hypoglycemia noted in patients taking ACEIs along with Antidiabetics.
© Use of NSAIDs in patients taking ACEIs may result in to renal dysfunction or decreased antihypertensive efficacy.
© Use of ACEIs during pregnancy is strongly discouraged.
© Caution should be used when administering ACEIs to a nursing mother.
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